Prognostic Significance of K-ras Codon 12 Mutations in Patients With Resected Stage I and II Non–Small-Cell Lung Cancer

作者: Stephen L. Graziano , Gary P. Gamble , Nancy B. Newman , Lynn Z. Abbott , Michelle Rooney

DOI: 10.1200/JCO.1999.17.2.668

关键词: Stage iiRespiratory diseaseGastroenterologyMutationMedicineCellLung cancerNon small cellPathologyPolymerase chain reactionIn patientInternal medicine

摘要: … 12 K-ras mutations were more common in adenocarcinomas than in squamous cell carcinomas. … of K-ras mutations. However, when the entire group was considered, the presence of …

参考文章(35)
Mitsudomi T, Minna Jd, Gazdar Af, Mulshine Jl, Viallet J, Linnoila Ri, Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines Oncogene. ,vol. 6, pp. 1353- 1362 ,(1991)
R. Rosell, J. Maestre, A. Ariza, A. Barnadas, M. Canela, E. Tolosa, J. L. Mate, P. Armengol, Z. Skacel, Shanrong Li, Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients. Oncogene. ,vol. 8, pp. 2407- 2412 ,(1993)
Gat Hawson, PV Zimmerman, P Parsons, MH Bint, Ploidy of Surgically Treated Primary Lung-Cancer Medical and Pediatric Oncology. ,vol. 15, pp. 133- 133 ,(1987)
J Maurel, A Pifarré, R Rosell, M Monzó, A Abad, J M de Anta, A Ariza, M P López, J J Sánchez, I Moreno, Molecular staging of non-small cell lung cancer according to K-ras genotypes. Clinical Cancer Research. ,vol. 2, pp. 1083- 1086 ,(1996)
S. Rodenhuis, S. S. Wagenaar, W. J. Mooi, A. J. M. Boot, R. J. C. Slebos, P. C. Van Bodegom, S. G. Evers, J. L. Bos, Incidence and Possible Clinical Significance of K- ras Oncogene Activation in Adenocarcinoma of the Human Lung Cancer Research. ,vol. 48, pp. 5738- 5741 ,(1988)
P Keohavong, J R Testa, J M Siegfried, A T Gillespie, J D Hunt, R Mera, T J Casey, Prognostic Value of Specific KRAS Mutations in Lung Adenocarcinomas Cancer Epidemiology, Biomarkers & Prevention. ,vol. 6, pp. 841- 847 ,(1997)
Shimokata K, Kuroishi T, Niimi T, Horio Y, Suyama M, Yamakawa K, Nakamura Y, Ueda R, Hibi K, Takahashi T, Prognostic Significance of p53 Mutations and 3p Deletions in Primary Resected Non-Small Cell Lung Cancer Cancer Research. ,vol. 53, pp. 1- 4 ,(1993)
Robert Iannone, Michael P. Sherman, Pamela E. B. Rodgers-Johnson, Mark A. Beilke, Carlos A. Mora, Rajnikant M. Amin, Susan R. Tinsley, Laurence D. Papsidero, Bernard J. Poiesz, Clarence J. Gibbs, HTLV-I DNA sequences in CNS tissue of a patient with tropical spastic paraparesis and HTLV-I-associated myelopathy. Journal of Acquired Immune Deficiency Syndromes. ,vol. 5, pp. 810- 816 ,(1992) , 10.1097/00126334-199208000-00007
Sydney D. Finkelstein, Determination of Tumor Aggressiveness in Colorectal Cancer by K-ras-2 Analysis Archives of Surgery. ,vol. 128, pp. 526- 532 ,(1993) , 10.1001/ARCHSURG.1993.01420170056008
J A Kern, R J Slebos, B Top, S Rodenhuis, D Lager, R A Robinson, D Weiner, D A Schwartz, C-erbB-2 expression and codon 12 K-ras mutations both predict shortened survival for patients with pulmonary adenocarcinomas. Journal of Clinical Investigation. ,vol. 93, pp. 516- 520 ,(1994) , 10.1172/JCI117001