Extension of the lod score: the mod score.

摘要: Abstract In 1955 Morton proposed the lod score method both for testing linkage between loci and estimating recombination fraction them. If a disease is controlled by gene at one of these loci, computation requires prior specification an underlying model that assigns probabilities genotypes from observed phenotypes. To address case studies diseases with unknown mode inheritance, we suggested Clerget-Darpoux et al. , 1986 extending function to so-called mod function. this function, variables are parameters. Maximizing over all parameters amounts maximizing probability marker data conditional on status. Under absence linkage, conforms chi-square distribution, extra degrees freedom in comparison MacLean 1993. The asymptotically maximum true Bonaiti-Pellie, 1992; Hodge Elston 1994. Consequently, power detect through will be highest when space models where maximization performed includes model. On other hand, must avoid overparametrization space. For example, approach applied affected sibpairs, only two constrained should used Knapp 1994 maximization. It also important emphasize existence strong correlation location there poor resolution susceptibility locus unknown. Of course, regardless statistics used. may candidate strategy potential effect disease. Since, however, it ignores information provided segregation disequilibrium alleles functional alleles, its discrimination genetic weak. MASC 1998 has been designed addressed more efficiently objectives approach.