High-molecular-weight tropomyosins localize to the contractile rings of dividing CNS cells but are absent from malignant pediatric and adult CNS tumors

摘要: Tropomyosin has been implicated in the control of actin filament dynamics during cell migration, morphogenesis, and cytokinesis. In order to gain insight into role tropomyosins division, we examined their expression developing neoplastic brain tissue. We found that high-molecular-weight are downregulated at birth, which correlates with glial differentiation withdrawal most cells from cycle. Expression these isoforms was restricted proliferative areas embryonic absent adult, where majority quiescent. However, they were induced under conditions became response injury. During cytokinesis, tropomyosin associated contractile ring. also investigated CNS tissues. Low-grade astrocytic tumors expressed tropomyosins, while highly malignant diverse origin did not (P ≤ 0.001). Furthermore, ring astrocytoma cells. Our findings suggest a for astrocyte although still able undergo division absence. Additionally, correlation between tumor grade suggests potentially useful as indicators grade. GLIA 42:25–35, 2003. © 2003 Wiley-Liss, Inc.