The quantitative assessment of physical dependence on opiates

摘要: Abstract A procedure for administering naloxone to narcotic-dependent individuals and a technique quantitating the ensuing acute withdrawal syndrome have been developed assess degree of physical dependence. Successive injections increasing doses produce controlled increase in severity signs symptoms as measured by subjective an objective assessment battery. There is good agreement between assessments global rating severity. The measures are, however, most sensitive score related duration current cycle drug abuse. Hand tremor, trapezius electromyogram heart rate are can be used combination form basis simplified shortened antagonist test