Auditory event-related potentials in methadone substituted opiate users.
作者： Grace Y Wang , Robert Kydd , Bruce R Russell
关键词: Cognition 、 Anesthesia 、 Event-related potential 、 User group 、 Opiate 、 Auditory event 、 Audiology 、 Methadone 、 Psychology 、 P200 、 Methadone maintenance
摘要: The effects of methadone maintenance treatment (MMT) on neurophysiological function are unclear. Using an auditory oddball paradigm, event-related potential (ERP) amplitudes and latencies were measured in 32 patients undertaking MMT, 17 opiate users who addicted but not receiving substitution 25 healthy control subjects. Compared with subjects, the MMT user groups showed increased P200 amplitude response to target stimuli. group also exhibited a decreased latency N200, greater number task-related errors than either subjects or MMT. There no significant differences P300 amplitude. However, it is noteworthy that frontal was controls. Our findings suggest altered sensory information processing associated history use remains there less marked ERP abnormalities those active users. deficits illicit likely be reduced during
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