UPLC-Q-TOF/MS-based screening and identification of the main flavonoids and their metabolites in rat bile, urine and feces after oral administration of Scutellaria baicalensis extract.
作者： Le-yue Du , Da-wei Qian , Er-xin Shang , Pei Liu , Shu Jiang
DOI: 10.1016/J.JEP.2015.04.039
关键词:
摘要: … Radix Scutellariae is one of the most important heat-clearing, dehumidifying traditional Chinese medicine. Previous reports have indicated that S. baicalensis may inhibit the growth of …
sci-hub.se 参考文章(39)
Gerhard Eisenbrand, Weici Tang, Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine ,(1992)
Tae Y. Yune, Jee Y. Lee, Chun M. Cui, Ho C. Kim, Tae H. Oh, Neuroprotective effect ofScutellaria baicalensison spinal cord injury in rats Journal of Neurochemistry. ,vol. 110, pp. 1276- 1287 ,(2009) , 10.1111/J.1471-4159.2009.06214.X
B.P. Burnett, Q. Jia, Y. Zhao, R.M. Levy, A Medicinal Extract ofScutellaria baicalensisandAcacia catechuActs as a Dual Inhibitor of Cyclooxygenase and 5-Lipoxygenase to Reduce Inflammation Journal of Medicinal Food. ,vol. 10, pp. 442- 451 ,(2007) , 10.1089/JMF.2006.255
Mina Hasegawa, Shigeo Takenaka, Mitsuru Kuwamura, Jyoji Yamate, Shingo Tsuyama, Urinary metabolic fingerprinting for amiodarone-induced phospholipidosis in rats using FT-ICR MS. Experimental and Toxicologic Pathology. ,vol. 59, pp. 115- 120 ,(2007) , 10.1016/J.ETP.2007.04.001
Russell J. Mortishire-Smith, Desmond O'Connor, Jose M. Castro-Perez, Jane Kirby, Accelerated throughput metabolic route screening in early drug discovery using high‐resolution liquid chromatography/quadrupole time‐of‐flight mass spectrometry and automated data analysis Rapid Communications in Mass Spectrometry. ,vol. 19, pp. 2659- 2670 ,(2005) , 10.1002/RCM.2111
Xiaoming Cai, Lijuan Zou, Jun Dong, Lili Zhao, Yuanyuan Wang, Qing Xu, Xingya Xue, Xiuli Zhang, Xinmiao Liang, Analysis of highly polar metabolites in human plasma by ultra-performance hydrophilic interaction liquid chromatography coupled with quadrupole-time of flight mass spectrometry. Analytica Chimica Acta. ,vol. 650, pp. 10- 15 ,(2009) , 10.1016/J.ACA.2009.01.054
Seigo Baba, Naomi Osakabe, Midori Natsume, Junji Terao, Orally administered rosmarinic acid is present as the conjugated and/or methylated forms in plasma, and is degraded and metabolized to conjugated forms of caffeic acid, ferulic acid and m-coumaric acid. Life Sciences. ,vol. 75, pp. 165- 178 ,(2004) , 10.1016/J.LFS.2003.11.028
José A. Ferreira, M. Rosário M. Domingues, Ana Reis, Mario A. Monteiro, Manuel A. Coimbra, Differentiation of isomeric Lewis blood groups by positive ion electrospray tandem mass spectrometry Analytical Biochemistry. ,vol. 397, pp. 186- 196 ,(2010) , 10.1016/J.AB.2009.10.034
Hua-Bin Li, Yue Jiang, Feng Chen, Separation methods used for Scutellaria baicalensis active components. Journal of Chromatography B. ,vol. 812, pp. 277- 290 ,(2004) , 10.1016/J.JCHROMB.2004.06.045
Thomas A. Baillie, Metabolism and toxicity of drugs. Two decades of progress in industrial drug metabolism Chemical Research in Toxicology. ,vol. 21, pp. 129- 137 ,(2008) , 10.1021/TX7002273