Features of trinucleotide repeat instability in vivo

摘要: Unstable repeats are associated with various types of cancer and have been implicated in more than 40 neurodegenerative disorders. Trinucleotide located non-coding coding regions the genome. Studies bacteria, yeast, mice man helped to unravel some features mechanism trinucleotide expansion. Looped DNA structures comprising processed during replication and/or repair generate deletions or expansions. Most vivo data consistent a model which expansion deletion occur by different mechanisms. In mammals, microsatellite instability is complex appears be influenced genetic, epigenetic developmental factors.