Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice.
作者： Kevin Manley , Thomas L. Shirley , Lorraine Flaherty , Anne Messer
DOI: 10.1038/70598
关键词:
摘要: … We re-derived Msh2 +/+ mice by mating Msh2 heterozygotes, one of which carried the HD transgene. We genotyped progeny for both the HD transgene and Msh2 by PCR (ref. 15). We …
nature.com
sci-hub.se 
researchgate.net 参考文章(28)
Mark Meuth, Robert G. Bristow, Armin H. Reitmair, Anne Jang, Richard P. Hill, Tak W. Mak, Tak W. Mak, Richard Fishel, Teresa Wilson, Robert Risley, Anil Ganesh, Samuel Benchimol, James Peacock, Mutator Phenotype in Msh2-deficient Murine Embryonic Fibroblasts Cancer Research. ,vol. 57, pp. 3765- 3771 ,(1997)
Russell G. Snell, John C. MacMillan, Jeremy P. Cheadle, Iain Fenton, Lazarus P. Lazarou, Peter Davies, Marcy E. MacDonald, James F. Gusella, Peter S. Harper, Duncan J. Shaw, Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease Nature Genetics. ,vol. 4, pp. 393- 397 ,(1993) , 10.1038/NG0893-393
Niels de Wind, Marleen Dekker, Anton Berns, Miroslav Radman, Hein te Riele, Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer Cell. ,vol. 82, pp. 321- 330 ,(1995) , 10.1016/0092-8674(95)90319-4
Sun Jung Kim, Bo Hwa Shon, Joo Hyun Kang, Kyung-Soo Hahm, Ook Joon Yoo, Young Sik Park, Kyung-Kwang Lee, Cloning of novel trinucleotide-repeat (CAG) containing genes in mouse brain Biochemical and Biophysical Research Communications. ,vol. 240, pp. 239- 243 ,(1997) , 10.1006/BBRC.1997.7643
S. E. Andrew, M. McKinnon, B. S. Cheng, A. Francis, J. Penney, A. H. Reitmair, T. W. Mak, F. R. Jirik, Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 1126- 1130 ,(1998) , 10.1073/PNAS.95.3.1126
Håkan Telenius, Berry Kremer, Y. Paul Goldberg, Jane Theilmann, Susan E. Andrew, Jutta Zeisler, Shelin Adam, Cheryl Greenberg, Elizabeth J. Ives, Lorne A. Clarke, Michael R. Hayden, Somatic and gonadal mosaicism of the Huntington disease gene CAG repeat in brain and sperm. Nature Genetics. ,vol. 6, pp. 409- 414 ,(1994) , 10.1038/NG0494-409
Y Trottier, V Biancalana, J L Mandel, Instability of CAG repeats in Huntington's disease: relation to parental transmission and age of onset. Journal of Medical Genetics. ,vol. 31, pp. 377- 382 ,(1994) , 10.1136/JMG.31.5.377
M. Duyao, A. Auerbach, A Ryan, F Persichetti, G. Barnes, S. McNeil, P Ge, J. Vonsattel, J. Gusella, A. Joyner, al. et, Inactivation of the mouse Huntington's disease gene homolog Hdh. Science. ,vol. 269, pp. 407- 410 ,(1995) , 10.1126/SCIENCE.7618107
N. Sugawara, F. Paques, M. Colaiacovo, J. E. Haber, Role of Saccharomyces cerevisiae Msh2 and Msh3 Repair Proteins in Double-Strand Break-Induced Recombination Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 9214- 9219 ,(1997) , 10.1073/PNAS.94.17.9214
A. Baross-Francis, S. E. Andrew, J. E. Penney, F. R. Jirik, Tumors of DNA mismatch repair-deficient hosts exhibit dramatic increases in genomic instability Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 8739- 8743 ,(1998) , 10.1073/PNAS.95.15.8739