2I-2 Quantification and MRI Validation of Regional Cardiac Contractile Dysfunction in Mice Post Myocardial Infarction Using High Resolution Ultrasound

摘要: High resolution 30 MHz ultrasound imaging was performed on the left ventricles (LV) of C57B1/6 mice post myocardial infarction (MI). Normal (no MI) were examined as control experiments. Ultrasound at 5-7 short axis slices and 4-5 long 1 mm intervals that encompass LV. Myocardial tissue displacement vectors measured using a 2D ultrasonic speckle tracking algorithm with sub-pixel resolution. The pixel block window size approximately 0.4 times search region 0.6 mm. extent contractile dysfunction cardiac dyssynchrony revealed in post-MI mouse LVs by regional strain analyses. Strain analyses from mid-ventricular based upon images compared to those obtained MRI, high levels correlation (R = 0.91 R 0.84 for radial circumferential strain, respectively). Displacement conducted multiple slices, 3D determined lines intersection summing vector components derived each orthogonal