Potential screening assays for individual radiation sensitivity and susceptibility and their current validation state.
作者： Maria Gomolka , Benjamin Blyth , Michel Bourguignon , Christophe Badie , Annette Schmitz
DOI: 10.1080/09553002.2019.1642544
关键词:
摘要: Purpose: The workshop on 'Individual Radiosensitivity and Radiosusceptibility' organized by MELODI CONCERT Malta in 2018, evaluated the current state of assays to identify sensitive susceptible subgroups. authors provide an overview potential screening detecting individuals showing moderate severe early late radiation reactions or are at increased risk develop cancer upon exposure.Conclusion: It is necessary separate clearly between tissue stochastic effects such as when comparing existing literature validate various test systems. Requirements for set up. reviewed that reliable robust. Sensitivity specificity regarded scrutinized modifying factors. Accuracy assay system required be more than 90% balance risks adverse against fail cure cancer. No assay/biomarker routine use. Assays have shown predictive radiosensitivity include SNPs, RILA assay, pATM assay. A tree guideline radiologists provided assist medical treatment decisions. Recommendations effective research setup common retrospective prospective cohorts/biobanks future tests.
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