The steroid RU486 induces UCP1 expression in brown adipocytes

摘要: RU486 (mifepristone), a potent antagonist at progesterone and glucocorticoid receptors (PR GR), is well known for its use in the termination of unwanted pregnancies, potential development oral contraceptives, treatment certain cancers other activities. Potentially, it could also play role obesity control, although few studies that have addressed this aspect focused mainly on central anti-glucocorticoid effects. We shown previously direct effect brown adipocytes culture when administered together with progesterone. The aim present work was to analyse effects expression uncoupling proteins (UCPs) adipocytes. In culture-grown, differentiated adipocytes, placed serum-free medium exclude presence or glucocorticoids, stimulated UCP1 both mRNA protein levels. These be mediated by PR, GR unknown mechanisms but do not seem due anti-progestin actions. results suggest steroid has action which useful stimulating non-shivering BAT thermogenesis therefore interest studies.