Therapeutic efficacy in BALB/C mice of extract from marine alga Canistrocarpus cervicornis (Phaeophyceae) against herpes simplex virus type 1

摘要: Studies with diterpenes from marine brown alga Canistrocarpus cervicornis showed the antiviral potential of products this in controlling replication HSV-1 and maintaining low cytotoxicity. Hence, aim work was to evaluate anti-herpetic efficacy C. extract ointment BALB/c mice. To test vivo, four groups mice (n = 5) were used: 1—untreated, 2—extract (2 % or 0.4 mg cm−2 dose−1), 3—Acyclovir cream (5 1.0 4—ointment base. The right midflank each mouse clipped depilated a chemical depilatory. After 2 days, skin area scratched inoculated HSV-1. ointments applied three times day over 16-day period, beginning 1 h after virus inoculation. development lesions continuously monitored scored. effect topical treatment on biochemical parameters body weight, two uninfected formed: an untreated group treated %). signs infection appeared second infection, while 10th experiment, base had significantly more severe than did that (p < 0.05) acyclovir 0,01). application not change hepatic, renal function suggesting has toxicity route administration. These results suggest may be useful reducing severity cutaneous lesions.