Risk factors of meconium aspiration syndrome developing into persistent pulmonary hypertension of newborn.

摘要: Clinical experience indicates that persistent pulmonary hypertension of the newborn (PPHN) is one major causes death in infants with meconium aspiration syndrome (MAS). We aimed to investigate risk factors associated MAS which lead PPHN order search for ways reduce mortality MAS. From 1995 2003, we conducted a retrospective study at China Medical University Hospital. compared MAS, including pattern fetal heart beat, mode delivery, apgar score, sex, gestational age, birth body weight, born or out infants, resuscitation before admission, first pH asphyxia, surfactant usage, pneumothorax, hemorrhage and shock diagnosis between non infants. During nine-year study, 362 were enrolled. There 64 (17.7%) 298 without PPHN. According univariant analysis, significant infant (p=0.007), change beat (p=0.0001), admission low (p=0.002), asphyxia (p<0.0001), pneumothorax (p=0.0004), (p<0.0002). Based on results logistic regression (p=0.04, odds ratio: 2.34), (p=0.02, 2.37) (p=0.001, 5.48). conclude are most important development Avoidance might be key incidence PPNH rate