Ubiquitination and the Ubiquitin–Proteasome System as regulators of transcription and transcription factorsin epithelial mesenchymal transition of cancer
作者： Ioannis A. Voutsadakis
DOI: 10.1007/S13277-012-0355-X
关键词:
摘要: Epithelial to Mesenchymal Transition (EMT) in cancer is a process that allows cells detach from neighboring cells, become mobile and metastasize shares many signaling pathways with development. Several molecular mechanisms which regulate oncogenic properties neoplastic such as proliferation, resistance apoptosis angiogenesis through transcription factors or other mediators are also regulators of EMT. These downstream are, their turn, regulated by ubiquitination the Ubiquitin–Proteasome System (UPS). Ubiquitination, covalent link small 76-amino acid protein ubiquitin target proteins, serves signal for degradation proteasome outcomes endocytosis, lysosome directing these proteins specific cellular compartments. This review discusses aspects regulation EMT UPS underlines its complexity focusing on regulating being ubiquitination.
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