Comparison of laparoscopic versus open gastrectomy for advanced gastric cancer: an updated meta-analysis.

摘要: Laparoscopic gastrectomy (LG) has been used as an alternative to open (OG) treat early gastric cancer. However, the use of LG for advanced cancer (AGC) in debate. Literature retrieval was performed by searching PubMed, EMBASE, and Cochrane library up July 2014. Potential studies comparing surgical effects between with OG were evaluated data extracted accordingly. Meta-analysis carried out using RevMan. The pooled risk ratio weighted mean difference (WMD) 95 % confidence interval (95 % CI) calculated. Overall, 26 included this meta-analysis. had some advantages over OG, including shorter hospitalization (WMD, −3.63, CI, −4.66 −2.60; P < 0.01), less blood loss −161.37, −192.55 −130.18; faster bowel recovery −0.78, −1.05 −0.50; earlier ambulation −0.95, −1.47 −0.44; P < 0.01). In terms oncological safety, could achieve similar lymph nodes −0.49, −1.78 0.81; P = 0.46), a lower complication rate [odds (OR), 0.71, 0.59 0.87; P < 0.01], overall survival (OS) disease-free (DFS) comparable OG. For AGCs, appeared short- long-term results. Although more time needed perform LG, it achieving postoperative recovery. Ongoing trials future help clarify controversial issue.