Helicobacter pylori in Iran: A systematic review on the association of genotypes and gastroduodenal diseases.

摘要: BACKGROUND : Helicobacter pylori ( H. ) infection is known as a major etiologic factor for variety of gastroduodenal diseases. In Iran, with high rate close to 90%, numerous studies have revealed many aspects interaction between the bacterium, mucosal surface and induction disease outcome. The organism genetically diverse several virulence factors are attributed more virulent strains. well-characterized cytotoxin associated gene A vacuolating A. distribution pattern genotypes its association status varies geographically. present review focused on genotyping in relation disorders different regions Iran. METHODS total, 398 were reported related our electronic search from 1995-2011. investigated 159 reports. Looking specifically at gastrointestinal tract disorders, most relevant reports including 37 papers selected. RESULTS We found no correlation cagA genotype majority studies, whereas vacA was demonstrated useful marker predicting results other such blood group antigen-binding adhesion A, induced by contact epithelium outer inflammatory protein duodenal ulcer promoting membrane their contradictory. CONCLUSIONS Although markers emphasized when outcomes some inconsistent researches scarcity data made any conclusion or even comparison impossible. Considering gap information observed during relating infection, further investigations suggested. KEYWORDS , Genotyping, Virulence, Gastroduodenal cagA, vacA, Iran