The Physiology and Genetics of Oxidative Stress in Mycobacteria.

摘要: During infection, Mycobacterium tuberculosis is exposed to a diverse array of microenvironments in the human host, each with its own unique set redox conditions. Imbalances environment bacillus or host serve as stimuli, which could regulate virulence. The ability M. evade immune response and cause disease largely owing capacity mycobacterium sense changes environment, such host-generated gases, carbon sources, pathological conditions, alter metabolism balance accordingly for survival. In this article we discuss sensors that are, date, known be present tuberculosis, Dos dormancy regulon, WhiB family, anti-σ factors, MosR, addition strategies neutralize free radicals, superoxide dismutases, catalase-peroxidase, thioredoxins, methionine sulfoxide reductases, among others. peculiar it appears have hierarchy buffers, namely, mycothiol ergothioneine. We current knowledge their biosynthesis, function, regulation. Ergothioneine still an enigma, although distinct overlapping functions mycothiol, enable protect against wide range toxic metabolites radicals generated by host. Developing approaches quantify intracellular status will us determine how altered signals environments mimic those encountered