Pathogenetic aspects of responsiveness to ondansetron (5-hydroxytryptamine type 3 receptor antagonist) in patients with primary fibromyalgia syndrome--a preliminary study.

摘要: Objective. To study the efficacy of 5-hydroxytryptamine type 3 receptor (5-HT-3R) antagonist (ondansetron) vs paracetamol in primary fibromyalgia (FM) syndrome. Methods. A double blind, crossover, latin square 21 patients with FM. Visual analog scale (VAS) and body drawings were used to record pain intensity. Functional symptoms determined for using a Likert-type self-developed protocol. Quantitative dolorimetry was applied assess number painful tender points average threshold. Serum serotonin levels measured by commercial ELISA. Results. marked improvement intensity VAS (p < 0.005), score 0.05), threshold 0.01) obtained ondansetron, whereas no seen paracetamol. After ondansetron treatment, there also significant reduction both functional headache 0.05). In who did not respond higher baseline 0.05) 0.01), lower compared those well. responsive group, differences level before after therapy, increase serum concentration observed nonresponders treatment. Conclusion. Ondansetron appears be an effective drug about 50% There may 2 subsets FM that differ clinically pathogenetically regard disturbance 5-HT-3R system.