The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice
作者： Birgit Ritschka , Tania Knauer-Meyer , Daniel Sampaio Gonçalves , Alba Mas , Jean-Luc Plassat
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摘要: Young mammals possess a limited regenerative capacity in some tissues, which is lost upon maturation. We investigated whether cellular senescence might play role such loss during liver regeneration. found that following partial hepatectomy, the senescence-associated genes p21, p16Ink4a, and p19Arf become dynamically expressed different cell types when decreases, but without full senescent response. However, we show treatment with senescence-inhibiting drug improves regeneration, by disrupting aberrantly prolonged p21 expression. This work suggests may initially develop from heterogeneous responses, senotherapeutic drugs be useful promoting organ
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