Alanine is a precursor in the biosynthesis of fumonisin B1 by Fusarium moniliforme.

作者: B. E. Branham , R. D. Plattner

DOI: 10.1007/BF01103109

关键词:

摘要: The biosynthesis of fumonisin B1 byFusarium moniliforme was studied in liquid culture. Stable isotope labeled alanine added as a precursor to static and shaken cultures ofF. moniliforme. Incorporation of13C and2H L-alanine into measured by GC-MS. Under culture conditions, 20.8 µg ml−1 FB1 were produced with 5.5% level incorporation intact, B1. shake much higher levels reaching 159–240 21 days after initiation. A lower incorporation, from 1.1–1.4%, observed under these conditions. reduced because the rapid metabolism combined high production resulted turnover added, percentage incorporation. evidence presented indicates that is incorporated intact

参考文章(19)
J.G. Pienaar, T.W. Naude, T. Stephanus Kellerman, Walter F.O. Marasas, Leukoencephalomacia : A mycotoxicosis of equidae caused by Fusarium moniliforme Sheldon Onderstepoort Journal of Veterinary Research. ,vol. 43, pp. 113- ,(1976)
Alfred H. Merrill, Cell regulation by sphingosine and more complex sphingolipids Journal of Bioenergetics and Biomembranes. ,vol. 23, pp. 83- 104 ,(1991) , 10.1007/BF00768840
Wentzel Ca Gelderblom, PG Thiel, TS Kellerman, JJ Van Der Lugt, Wfo Marasas, Jaw Coetzer, Leukoencephalomalacia in a horse induced by fumonisin B1 isolated from Fusarium moniliforme. Onderstepoort Journal of Veterinary Research. ,vol. 55, pp. 197- 203 ,(1988)
E. Wang, W.P. Norred, C.W. Bacon, R.T. Riley, A.H. Merrill, Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. Journal of Biological Chemistry. ,vol. 266, pp. 14486- 14490 ,(1991) , 10.1016/S0021-9258(18)98712-0
G. S. Shephard, E. W. Sydenham, P. G. Thiel, W. C. A. Gelderblom, Quantitative Determination of Fumonisins B1 and B2 by High-Performance Liquid Chromatography with Fluorescence Detection Journal of Liquid Chromatography & Related Technologies. ,vol. 13, pp. 2077- 2087 ,(1990) , 10.1080/01483919008049014
W C Gelderblom, K Jaskiewicz, W F Marasas, P G Thiel, R M Horak, R Vleggaar, N P Kriek, Fumonisins--novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Applied and Environmental Microbiology. ,vol. 54, pp. 1806- 1811 ,(1988) , 10.1128/AEM.54.7.1806-1811.1988
W.C.A. Gelderblom, W.F.O. Marasas, K. Jaskiewicz, S. Combrinck, D.J. van Schalkwyk, Cancer promoting potential of different strains of Fusarium moniliforme in a short-term cancer initiation/promotion assay. Carcinogenesis. ,vol. 9, pp. 1405- 1409 ,(1988) , 10.1093/CARCIN/9.8.1405
Ronald D. Plattner, Darcy D. Shackelford, Biosynthesis of labeled fumonisins in liquid cultures of Fusarium moniliforme Mycopathologia. ,vol. 117, pp. 17- 22 ,(1992) , 10.1007/BF00497274
P. E. Braun, E. E. Snell, The biosynthesis of dihydrosphingosine in cell-free preparations of Hansenula ciferri. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 58, pp. 298- 303 ,(1967) , 10.1073/PNAS.58.1.298
W.C.A. Gelderblom, N.P.J. Kriek, W.F.O. Marasas, P.G. Thiel, Toxicity and carcinogenicity of the fusanum monilzforine metabolite, fumonisin B1, in rats. Carcinogenesis. ,vol. 12, pp. 1247- 1251 ,(1991) , 10.1093/CARCIN/12.7.1247