ATP-Dependent Chromatin Remodeling During Cortical Neurogenesis.

摘要: The generation of individual neurons (neurogenesis) during cortical development occurs in discrete steps that are subtly regulated and orchestrated to ensure normal histogenesis function the cortex. Notably, various gene expression programs known critically drive many facets neurogenesis with a high level specificity brain development. Typically, precise regulation patterns ensures key events like proliferation differentiation neural progenitors, specification neuronal subtypes, as well migration maturation developing cortex occur properly. ATP-dependent chromatin remodeling complexes regulate through utilization energy from ATP hydrolysis reorganize structure. These characteristically multimeric, some capable adopting functionally distinct conformations via subunit reconstitution perform specific roles major aspects neurogenesis. In this review, we highlight functions such remodelers We also bring together proposed mechanisms by which individually or concert, specifically modulate vital