Genetic variants in m6A modification core genes are associated with glioma risk in Chinese children
作者： Jing He , Huiran Lin , Huiran Lin , Ailing Luo , Zhenjian Zhuo
DOI: 10.1016/J.OMTO.2020.12.013
关键词:
摘要: Glioma is a highly heritable disease with strong genetic component. The N6-methyladenosine (m6A) modification core genes play important roles in the context of cancer. However, effects polymorphisms m6A on risk pediatric glioma remain undefined. Here, we intended to demonstrate relationship between 24 functional single-nucleotide (SNPs) eight and risk. Case-control design multinomial logistic regression were used develop models estimate while accounting for subtypes glioma. A total 171 cases 228 controls from South China genotyped using TaqMan assay. WTAP rs7766006, YTHDF2 rs3738067, FTO rs9939609 variants conferred statistically significant increased glioma, respectively. YTHDC1 rs2293595, rs3813832, rs8047395 associated inverse association associations more predominant stratification analyses certain subgroups. Functional annotations revealed that rs7766006 rs3738067 could be potential by increasing expression mRNA, Overall, these findings implicate as playing role etiology.
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