VIROLOGIC STUDIES OF ACUTE RESPIRATORY DISEASE IN YOUNG ADULTS V. CORONAVIRUS 229E INFECTIONS DURING SIX YEARS OF SURVEILLANCE

摘要: Hamre, D. and M. Beem (DepL Pediatrics, Univ. of Chicago, III. 60637). Virologic studies acute respiratory disease in young adults. V. Coronavirus 229E infections during six years surveillance. Am J Epidemiol 96: 94–106, 1972.—In a surveillance study medical students that spanned consecutive seasons between 1961 1968 encompassed 937 student observation, infection with coronavirus was identified by virus isolation serologic studies. Virus 12 infections, 8 one season, 4 another. Complement fixing (CF) antibody titer rises 133 occurred all surveillance, involving from 15 to 35% three “high” prevalence, 1 5% intervening “low” prevalence. Infection winter-spring seasonal pattern associated illness not clinically distinctive. Neutralizing commonly present the sera students. The level this did appear influence occurrence of, or likelihood with, reinfection as judged CF seroconversion; however, frequency significant rise neutralizing inversely related pre-infection levels antibody. other common viruses stimulate 229E.