Ferritin: A Platform for MRI Contrast Agents Delivery
作者： Maria Ruggiero , Diego Alberti , Valeria Bitonto , Simonetta Geninatti Crich
DOI: 10.3390/INORGANICS7030033
关键词:
摘要: The search for high relaxivities and increased specificity continues to be central the development of paramagnetic contrast agents magnetic resonance imaging (MRI). Ferritin, due its unique surface properties, architecture, biocompatibility, has emerged as a natural nanocage that can potentially help reach both these goals. This review aims highlight recent advances in use ferritin nanoplatform delivery metal-based MRI (containing Gd3+, Mn2+, or Fe2O3) alone combination with active molecules used therapeutic purposes. collected results unequivocally show agent leads more accurate cancer cells significantly improved targeted therapy.
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sci-hub.se 参考文章(76)
P. Stephen Patrick, Tiago B. Rodrigues, Mikko I. Kettunen, Scott K. Lyons, André A. Neves, Kevin M. Brindle, Development of Timd2 as a reporter gene for MRI. Magnetic Resonance in Medicine. ,vol. 75, pp. 1697- 1707 ,(2016) , 10.1002/MRM.25750
Miroslaw Janowski, Anna Andrzejewska, Adam Nowakowski, Jeff Bulte, Assaf Gilad, Piotr Walczak, Barbara Lukomska, Pre- and postmortem imaging of transplanted cells International Journal of Nanomedicine. ,vol. 10, pp. 5543- 5559 ,(2015) , 10.2147/IJN.S83557
Dario Livio Longo, Francesca Arena, Lorena Consolino, Paolo Minazzi, Simonetta Geninatti-Crich, Giovanni Battista Giovenzana, Silvio Aime, Gd-AAZTA-MADEC, an improved blood pool agent for DCE-MRI studies on mice on 1 T scanners Biomaterials. ,vol. 75, pp. 47- 57 ,(2016) , 10.1016/J.BIOMATERIALS.2015.10.012
Simonetta Geninatti Crich, Juan Carlos Cutrin, Stefania Lanzardo, Laura Conti, Ferenc K. Kálmán, Ibolya Szabó, Néstor R. Lago, Achille Iolascon, Silvio Aime, Mn-loaded apoferritin: a highly sensitive MRI imaging probe for the detection and characterization of hepatocarcinoma lesions in a transgenic mouse model. Contrast Media & Molecular Imaging. ,vol. 7, pp. 281- 288 ,(2012) , 10.1002/CMMI.492
Aline Hocq, Michel Luhmer, Sven Saussez, Stéphane Louryan, Pierre Gillis, Yves Gossuin, Effect of magnetic field and iron content on NMR proton relaxation of liver, spleen and brain tissues. Contrast Media & Molecular Imaging. ,vol. 10, pp. 144- 152 ,(2015) , 10.1002/CMMI.1610
Xiaoya He, Jinhua Cai, Bo Liu, Yi Zhong, Yong Qin, Cellular magnetic resonance imaging contrast generated by the ferritin heavy chain genetic reporter under the control of a Tet-On switch Stem Cell Research & Therapy. ,vol. 6, pp. 207- 207 ,(2015) , 10.1186/S13287-015-0205-Z
Jian Han, William E. Seaman, Xiumin Di, Wei Wang, Mark Willingham, Frank M. Torti, Suzy V. Torti, Iron Uptake Mediated by Binding of H-Ferritin to the TIM-2 Receptor in Mouse Cells PLoS ONE. ,vol. 6, pp. e23800- ,(2011) , 10.1371/JOURNAL.PONE.0023800
Dipanjan Pan, Shelton D. Caruthers, Angana Senpan, Ann H. Schmieder, Samuel A. Wickline, Gregory M. Lanza, Revisiting an old friend: manganese-based MRI contrast agents. Wiley Interdisciplinary Reviews-nanomedicine and Nanobiotechnology. ,vol. 3, pp. 162- 173 ,(2011) , 10.1002/WNAN.116
Pascal H. Fries, Elie Belorizky, Enhancement of the water proton relaxivity by trapping Gd3+ complexes in nanovesicles Journal of Chemical Physics. ,vol. 133, pp. 024504- 024504 ,(2010) , 10.1063/1.3456987
Silvio Aime, Claudia Cabella, Sebastiano Colombatto, Simonetta Geninatti Crich, Eliana Gianolio, Fabio Maggioni, Insights into the use of paramagnetic Gd(III) complexes in MR-molecular imaging investigations. Journal of Magnetic Resonance Imaging. ,vol. 16, pp. 394- 406 ,(2002) , 10.1002/JMRI.10180