A Psychological Perspective on Factors Predicting Prophylactic Salpingo-Oophorectomy in a Sample of Italian Women from the General Population. Results from a Hypothetical Study in the Context of BRCA Mutations.

摘要: The aim of this study was to assess attitudes toward ovarian cancer risk management options for BRCA mutation carriers in healthy Italian women, and identify predictors the preference reducing salpingo-oophorectomy (RRSO) over surveillance. One hundred eighty-one women aged 30–45 completed a questionnaire about preferences, knowledge, perception, socio-demographic information. Participants were randomly presented with pamphlet BRCA1 or BRCA2 mutation-specific testing, consequences testing preventive carriers, they stratified by having children not age group. Surveillance preferred option (64.6%), followed RRSO (24.3%). Although is only effective strategy available most faced first time may consider it as their choice. Predictors associated higher likelihood prefer surgery surveillance were: knowing that life expectancy longer surgery, perceived comprehension previous knowledge anticipated worry developing cancer, feelings risk. Childbearing intentions effect childbearing on choice lower surgery. Further research needed confirm role factors identified order promote informed decision-making RRSO.