High expression of the p53 isoform γ is associated with reduced progression-free survival in uterine serous carcinoma

摘要: Uterine serous carcinoma (USC) is a rare but aggressive subtype of endometrial carcinoma. Large-scale comprehensive efforts have resulted in an improved molecular understanding its pathogenesis, and the p53 pathway has been proposed as key player potentially targetable. Here we attempt to further portray USC by assessing isoform expression. We applied quantitative Real-Time PCRs (RT-qPCR) for expression analyses total mRNA well distinction p53β, p53γ, amino-terminal truncated Δ40p53 Δ133p53 retrospective cohort 37 patients with USC. TP53 mutation status was assessed targeted massive parallel sequencing. Findings were correlated clinical data. The landscape USCs heterogeneous dominated Δ133p53, while distinct p53β p53γ variants found at much lower levels. profiles varied between samples, their independent status. high relative be associated reduced progression-free survival (PFS). This first indication that elevated PFS single-center study may offer some insight USC, validation studies are crucial understand context-dependent tissue-specific role network gynecological cancer.