EFFECTS OF NEUROHYPOPHYSEAL PEPTIDE HORMONES ON ALCOHOL DEPENDENCE AND WITHDRAWAL

摘要: The effect of oxytocin (OXT) and vasopressin (VP) on alcohol withdrawal was investigated. CFLP mice were treated with alternating daily injections tert-butanol ethanol for four days, which resulted in physical dependence ethanol. severity symptoms assessed by picrotoxin. lowest dose (0.02 IU) each the peptides precipitated tonic convulsions, while higher doses different tendencies. OXT-treated displayed milder response to increasing peptide (0.2-2.0 IU). VP showed a U-shaped dose-response effect. highest (2.0 increased occurrence convulsions frequency deaths.