Effects of oxytocin on nicotine withdrawal in rats.
作者： Katherine E. Manbeck , David Shelley , Clare E. Schmidt , Andrew C. Harris
DOI: 10.1016/J.PBB.2013.11.002
关键词:
摘要: Abstract Development of medications that attenuate symptoms nicotine withdrawal may be useful for facilitating smoking cessation. The neuropeptide oxytocin (OXY) decreases signs and other addiction-related effects several drugs abuse in animals, but has not been examined a preclinical model addiction. goal this study was to examine the OXY on rats, measured as increases somatic elevations intracranial self-stimulation (ICSS) thresholds (anhedonia-like behavior) during antagonist-precipitated from chronic infusion. Effects baseline ICSS non-dependent rats were also evaluated. (0.06 – 1.0 mg/kg, i.p.) blocked withdrawal-induced nicotine-dependent without affecting rats. In contrast, did affect thresholds. Relatively high doses (0.75 or 2.0 mg/kg) elevated These findings demonstrate blocks withdrawal. ability higher elevate reflect an aversive and/or motoric effect. data suggest OXY-based treating component syndrome, effective attenuating anhedonia.
sci-hub.se 参考文章(71)
David H. Malin, Pilar Goyarzu, Rodent Models of Nicotine Withdrawal Syndrome Handbook of experimental pharmacology. ,vol. 192, pp. 401- 434 ,(2009) , 10.1007/978-3-540-69248-5_14
I S McGregor, P D Callaghan, G E Hunt, From ultrasocial to antisocial: a role for oxytocin in the acute reinforcing effects and long‐term adverse consequences of drug use? British Journal of Pharmacology. ,vol. 154, pp. 358- 368 ,(2009) , 10.1038/BJP.2008.132
Mark P. Epping-Jordan, Shelly S. Watkins, George F. Koob, Athina Markou, Dramatic decreases in brain reward function during nicotine withdrawal Nature. ,vol. 393, pp. 76- 79 ,(1998) , 10.1038/30001
Louis J. Pellegrino, Anna J. Cushman, A stereotaxic atlas of the rat brain Published in <b>1967</b> in New York NY) by Appleton-Century-Crofts. ,(1967)
Tracey A. Baskerville, Alison J. Douglas, Dopamine and Oxytocin Interactions Underlying Behaviors: Potential Contributions to Behavioral Disorders CNS Neuroscience & Therapeutics. ,vol. 16, ,(2010) , 10.1111/J.1755-5949.2010.00154.X
Dean S. Carson, Glenn E. Hunt, Adam J. Guastella, Lachlan Barber, Jennifer L. Cornish, Jonathon C. Arnold, Aurelie A. Boucher, Iain S. McGregor, Systemically administered oxytocin decreases methamphetamine activation of the subthalamic nucleus and accumbens core and stimulates oxytocinergic neurons in the hypothalamus Addiction Biology. ,vol. 15, pp. 448- 463 ,(2010) , 10.1111/J.1369-1600.2010.00247.X
ZOLTÁN SARNYAI, Oxytocin as a potential mediator and modulator of drug addiction Addiction Biology. ,vol. 16, pp. 199- 201 ,(2011) , 10.1111/J.1369-1600.2011.00332.X
EFFECTS OF NEUROHYPOPHYSEAL PEPTIDE HORMONES ON ALCOHOL DEPENDENCE AND WITHDRAWAL Alcohol and Alcoholism. ,vol. 22, pp. 71- 74 ,(1987) , 10.1093/OXFORDJOURNALS.ALCALC.A044668
M Ohlin, J Trojnar, S Lundin, K Hansson, H I Bengtsson, P Melin, A Broeders, Pharmacokinetic and pharmacologic properties of antiuterotonic oxytocin analogs in the rat. Journal of Pharmacology and Experimental Therapeutics. ,vol. 264, pp. 783- 788 ,(1993)
George F. Koob, Luis Stinus, Shelly S. Watkins, Athina Markou, Reward and Somatic Changes during Precipitated Nicotine Withdrawal in Rats: Centrally and Peripherally Mediated Effects , Journal of Pharmacology and Experimental Therapeutics. ,vol. 292, pp. 1053- 1064 ,(2000)