Layering, bundling, and azimuthal orientations in dense phases of nucleosome core particles

作者: A G Cherstvy , R Everaers

DOI: 10.1088/0953-8984/18/50/003

关键词:

摘要: We propose an idea how the helical pattern of charges on surface DNA can affect electrostatic interactions nucleosome core particles in their columnar and crystalline phases as well chromatin. For bilayers nucleosomes, we suggest that mutual azimuthal orientations neighbouring NCPs are quantized with angle ≈π/4. a similar mechanism DNA-mediated inter-nucleosome might stabilize new chromatin-like bundled nucleosomes which have not yet been observed.

参考文章(54)
R. S. Edayathumangalam, P. Weyermann, J. M. Gottesfeld, P. B. Dervan, K. Luger, Molecular recognition of the nucleosomal “supergroove” Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 6864- 6869 ,(2004) , 10.1073/PNAS.0401743101
Andrey G. Cherstvy, Roland G. Winkler, Complexation of semiflexible chains with oppositely charged cylinder. Journal of Chemical Physics. ,vol. 120, pp. 9394- 9400 ,(2004) , 10.1063/1.1707015
Stéphanie Mangenot, Amélie Leforestier, Patrice Vachette, Dominique Durand, Françoise Livolant, Salt-Induced Conformation and Interaction Changes of Nucleosome Core Particles Biophysical Journal. ,vol. 82, pp. 345- 356 ,(2002) , 10.1016/S0006-3495(02)75399-X
Alexei A. Kornyshev, Dominic J. Lee, Sergey Leikin, Aaron Wynveen, Steven B. Zimmerman, Direct Observation of Azimuthal Correlations between DNA in Hydrated Aggregates Physical Review Letters. ,vol. 95, pp. 148102- ,(2005) , 10.1103/PHYSREVLETT.95.148102
D.C. Rau, V.A. Parsegian, Direct measurement of temperature-dependent solvation forces between DNA double helices Biophysical Journal. ,vol. 61, pp. 260- 271 ,(1992) , 10.1016/S0006-3495(92)81832-5
Andrey G. Cherstvy, Alexei A. Kornyshev, Sergey Leikin, Temperature-Dependent DNA Condensation Triggered by Rearrangement of Adsorbed Cations Journal of Physical Chemistry B. ,vol. 106, pp. 13362- 13369 ,(2002) , 10.1021/JP026343W
J. T. Finch, L. C. Lutter, D. Rhodes, R. S. Brown, B. Rushton, M. Levitt, A. Klug, Structure of nucleosome core particles of chromatin Nature. ,vol. 269, pp. 29- 36 ,(1977) , 10.1038/269029A0
A. C. Cowley, N. L. Fuller, R. P. Rand, V. A. Parsegian, Measurement of repulsive forces between charged phospholipid bilayers Biochemistry. ,vol. 17, pp. 3163- 3168 ,(1978) , 10.1021/BI00608A034
A. A. Kornyshev, S. Leikin, Sequence recognition in the pairing of DNA duplexes. Physical Review Letters. ,vol. 86, pp. 3666- 3669 ,(2001) , 10.1103/PHYSREVLETT.86.3666