HOTAIR is a predictive and prognostic biomarker for patients with advanced gastric adenocarcinoma receiving fluorouracil and platinum combination chemotherapy.

摘要: Accumulating evidence suggests that long non-coding RNA (lncRNA) HOTAIR participates in many types of cancer such as gastric and may confer malignant phenotype to tumor cells. Fluorouracil platinum combination chemotherapy is the first line therapy for cancer. However, it still unknown whether influences outcome patients treated with chemotherapy. This study aimed evaluate association expression prognosis advanced adenocarcinoma (GA) receiving fluorouracil based We examined levels 168 GA samples using quantitative real-time PCR analyzed its relationship clinical features Compared paracancerous tissues, was significantly upregulated especially more cases. High an independent poor prognostic factor GA. Further stratification analyses revealed between survival remained significant subgroup TNM stages IIIA IIIB, poorly differentiated, smaller tumors. In conclusion, our results provide be served a biomarker predicts which patient will benefit from