Bovine γδ T Cells Are a Major Regulatory T Cell Subset

摘要: In humans and mice, γδ T cells represent <5% of the total circulating lymphocytes. contrast, cell compartment in ruminants accounts for 15–60% mononuclear Despite existence CD4+CD25high Foxp3+ bovine system, these are neither anergic nor suppressive. We present evidence showing that major regulatory subset peripheral blood. These spontaneously secrete IL-10 proliferate response to IL-10, TGF-β, contact with APCs. IL-10–expressing inhibit Ag-specific nonspecific proliferation CD4+ CD8+ vitro. APC subsets expressing TFG-β regulate producing IL-10. propose a population system.