Acute infection with bovine viral diarrhea virus of low or high virulence leads to depletion and redistribution of WC1(+) γδ T cells in lymphoid tissues of beef calves.
作者： Roberto A. Palomares , Kaori Sakamoto , Heather L. Walz , Kenny V. Brock , David J. Hurley
DOI: 10.1016/J.VETIMM.2015.07.016
关键词:
摘要: The objective of this study was to determine the abundance and distribution γδ T lymphocytes in lymphoid tissue during acute infection with high (HV) or low virulence (LV) non-cytopathic bovine viral diarrhea virus (BVDV) beef calves. This performed using samples from a previous experiment which thirty calves were randomly assigned 1 3 groups: LV [n=10; animals inoculated intranasally (IN) BVDV-1a (strain SD-1)], HV IN BVDV-2 1373)], control (n=10; cell culture medium). On day 5 post inoculation, euthanized, spleen mesenteric lymph nodes (MLN) collected assess WC1(+) cells. A higher proportion challenged BVDV showed signs apoptosis cytophagy MLN compared group. significantly lower number cells observed groups than (P<0.05). In conclusion, resulted depletion mucosal systemic tissues at five days after challenge reduction studied could be also due lymphocyte trafficking other tissues.
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