Distribution of viral antigen and development of lesions after experimental infection with highly virulent bovine viral diarrhea virus type 2 in calves.
作者： Elisabeth M. Liebler-Tenorio , Julia F. Ridpath , John D. Neill
DOI: 10.2460/AJVR.2002.63.1575
关键词:
摘要: Objective—To correlate tissue distribution with development of lesions after experimental infection a virulent strain noncytopathic bovine viral diarrhea virus (BVDV) type 2 in calves. Animals—Ten 14-day-old and two 2-month-old colostrum-deprived Procedure—Calves were intranasally inoculated BVDV type-2 1373 from an outbreak clinically severe (BVD). Two calves served as noninfected controls. each euthanatized on postinoculation days 3, 6, 12, 1 8, 9, 13, 14. Tissues collected for immunohistologic histologic examination. Results—Inoculated developed nonspecific clinical signs characterized by high fever decreased numbers leukocytes thrombocytes. Viral antigen was detected focally lymphoid tissues day 3. On 14, became increasingly widespread throughout organs tissues. associated depl...
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