Systemic activation of Toll-like receptor 2 suppresses mitochondrial respiration and exacerbates hypoxic-ischemic injury in the developing brain.
作者： Amin Mottahedin , Pernilla Svedin , Syam Nair , Carl-Johan Mohn , Xiaoyang Wang
关键词:
摘要: Infection and inflammation are known risk factors for neonatal brain injury. Mycoplasma Gram-positive bacteria, which Toll-like receptor 2 (TLR2) plays a key role in recognition inflammatory response, among the most common pathogens perinatal period. Here, we report that systemic activation of TLR2 by Pam3CSK4 (P3C) increases neural tissue loss demyelination induced subsequent hypoxia-ischemia (HI) mice. High-resolution respirometry isolated mitochondria revealed P3C suppresses ADP-induced oxidative phosphorylation, main pathway cellular energy production. The results suggest infection might contribute to HI-induced failure.
sagepub.com
sci-hub.se 参考文章(26)
Xiaoyang Wang, Anna‐Lena Leverin, Wei Han, Changlian Zhu, Bengt R. Johansson, Etienne Jacotot, Vadim S. Ten, Neil R. Sims, Henrik Hagberg, Isolation of brain mitochondria from neonatal mice. Journal of Neurochemistry. ,vol. 119, pp. 1253- 1261 ,(2011) , 10.1111/J.1471-4159.2011.07525.X
Randy L. Hunter, Natasa Dragicevic, Kristen Seifert, Dong Young Choi, Mei Liu, Hyoung-Chun Kim, Wayne A. Cass, Patrick G. Sullivan, Guoying Bing, Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system. Journal of Neurochemistry. ,vol. 100, pp. 1375- 1386 ,(2007) , 10.1111/J.1471-4159.2006.04327.X
Shreela S. Pauliah, Seetha Shankaran, Angie Wade, Ernest B. Cady, Sudhin Thayyil, Therapeutic Hypothermia for Neonatal Encephalopathy in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis PLoS ONE. ,vol. 8, pp. e58834- ,(2013) , 10.1371/JOURNAL.PONE.0058834
Tobias Strunk, Terrie Inder, Xiaoyang Wang, David Burgner, Carina Mallard, Ofer Levy, Infection-induced inflammation and cerebral injury in preterm infants Lancet Infectious Diseases. ,vol. 14, pp. 751- 762 ,(2014) , 10.1016/S1473-3099(14)70710-8
Fang Hua, Jing Ma, Tuanzhu Ha, Jim Kelley, David L. Williams, Race L. Kao, John H. Kalbfleisch, I. William Browder, Chuanfu Li, Preconditioning with a TLR2 specific ligand increases resistance to cerebral ischemia/reperfusion injury Journal of Neuroimmunology. ,vol. 199, pp. 75- 82 ,(2008) , 10.1016/J.JNEUROIM.2008.05.009
Bobbi Fleiss, Cally J Tann, Vincent Degos, Stéphanie Sigaut, Juliette Van Steenwinckel, Anne-Laure Schang, Anton Kichev, Nicola J Robertson, Carina Mallard, Henrik Hagberg, Pierre Gressens, Inflammation-induced sensitization of the brain in term infants Developmental Medicine & Child Neurology. ,vol. 57, pp. 17- 28 ,(2015) , 10.1111/DMCN.12723
Eiji Kohmura, Kazuo Yamada, Toru Hayakawa, Akira Kinoshita, Katsumi Matsumoto, Heitaro Mogami, Hippocampal neurons become more vulnerable to glutamate after subcritical hypoxia: an in vitro study. Journal of Cerebral Blood Flow and Metabolism. ,vol. 10, pp. 877- 884 ,(1990) , 10.1038/JCBFM.1990.144
Ana Cristina Rego, Maria Sancha Santos, Catarina Resende Oliveira, Glutamate-mediated inhibition of oxidative phosphorylation in cultured retinal cells Neurochemistry International. ,vol. 36, pp. 159- 166 ,(2000) , 10.1016/S0197-0186(99)00107-2
Saskia Eklind, Carina Mallard, Anna-Lena Leverin, Erik Gilland, Klas Blomgren, Inger Mattsby-Baltzer, Henrik Hagberg, Bacterial endotoxin sensitizes the immature brain to hypoxic--ischaemic injury. European Journal of Neuroscience. ,vol. 13, pp. 1101- 1106 ,(2001) , 10.1046/J.0953-816X.2001.01474.X
L. Stridh, A. Mottahedin, M. E. Johansson, R. C. Valdez, F. Northington, X. Wang, C. Mallard, Toll-Like Receptor-3 Activation Increases the Vulnerability of the Neonatal Brain to Hypoxia–Ischemia The Journal of Neuroscience. ,vol. 33, pp. 12041- 12051 ,(2013) , 10.1523/JNEUROSCI.0673-13.2013