Time to take human embryo culture seriously

摘要: Study question Is it important that end-users know the composition of human embryo culture media? Summary answer We argue there is as strong case for full transparency concerning media intended use. What known already Published data suggest may influence phenotype offspring. design, size, duration A review literature was carried out. Participants/materials, setting, methods Data potential effects on development were assessed and recommendations users made. Main results role chance The safety ART procedures, especially with respect to health offspring, major importance. There are reports from indicating a possible effect conditions, including media, fetal development. Since introduction commercially available has been rapid different formulations, often not fully documented, disclosed or justified. now evidence environment early exposed can cause reprogramming embryonic growth leading alterations in trajectory, birthweight, childhood long-term disease Type II diabetes cardiovascular problems. mechanism this likely be epigenetic changes during preimplantation period In present paper ESHRE working group summarizes knowledge related makes recommendations. Limitations, reasons caution still need large prospective randomized trials further elucidate link between used do presently if phenotypic induced by vitro represent problem Wider implications findings indicate demanding compositions scientific rationale behind media. funding/competing interests This work funded European Society Human Reproduction Embryology. No competing declare.