Survival in infants with Down syndrome, Metropolitan Atlanta, 1979-1998.

摘要: Objective Factors influencing survival among persons with Down syndrome (DS) are not well understood. We sought to evaluate of infants DS and potential prognostic factors. Study design Infants who were born alive during 1979 1998 identified using the Metropolitan Atlanta Congenital Defects Program (MACDP), a population-based surveillance system. To document vital status, we used data from hospital records, National Death Index (NDI), Georgia records. estimated probability Kaplan-Meier product limit method hazard ratios Cox proportional hazards model. Results Survival 1 year was 92.9% (95% CI: 90.9-94.9) 10 years 88.6% 85.0-92.2). Univariate analysis demonstrated that black maternal race, low birth weight, preterm birth, lower paternal education, presence heart defects, other major congenital anomalies important After multivariate analysis, an interaction between race defects significantly associated mortality risk. Conclusions A racial disparity is apparent in for children syndrome. Further study needed elucidate possible reasons disparity.