Plasma TM2-PK levels in mycosis fungoides patients.

摘要: Aerobic glycolysis increases in tumor cells and pyruvate kinase (PK) is one of the key enzymes involved; PK exists different isoforms various tissues. Tumor M2-PK (TM2-PK) these its expression has been observed cells, including lymphocytes, lymphoproliferative disorders. The present study aimed to compare plasma levels TM2-PK serum two established markers disorders-lactate dehydrogenase (LDH) β-2 microglobulin, evaluate role drug monitorization disease activity mycosis fungoides (MF) patients. included 27 MF patients 46 healthy controls. Among patients, 18 were stage IA, 6 IB, 1 was IIA, 2 III. Plasma TM2-PK, LDH microglobulin controls measured using ELISA technique, a kinetic method, chemiluminescent assay, respectively. Measurements repeated patient group posttreatment. Median LDH, level 22 U mL⁻¹, 375 L⁻¹, 1,831 ng did not significantly differ between controls; however, higher 17 that remission from their pre-therapy levels. Based on cut-off point 17.5 sensitivity specificity for diagnosing 55.6 60.9%, most sensitive marker (63%), while specific marker. Furthermore, increased when it analyzed combination as parallel tests with (86%), 32%. In serial analysis, 98%, 5%. Statistically significant agreement also noted may be useful MF, especially early-stage because proliferates slowly. We think should investigated advanced-stage or other types cutaneous T-cell lymphomas; particular, markers.