The rs1447295 and DG8S737 markers on chromosome 8q24 and cancer risk in the Polish population.
作者： Dominika Wokołorczyk , Bartomiej Gliniewicz , Marcin Stojewski , Andrzej Sikorski , Elibieta Złowocka
DOI: 10.1097/CEJ.0B013E32832945C3
关键词:
摘要: Several recent association studies implicate three neighbouring regions of chromosome 8q24 as the site prostate cancer susceptibility loci. One region contains both a microsatellite marker DG8S737 and single nucleotide polymorphism rs1447295. Both have been consistently associated with risk in several populations. However, to date not inquired whether this particular extends other sites. We genotyped 3822 cases various sites 1807 controls for rs1447295 polymorphism. A positive was seen cancer, but any studied [odds ratios (ORs) ranging from 0.8 1.1]. Prostate were rs1447285 DG8S737. Significant ORs observed allele (OR= 1 .4; P=0.01) -8 . 6 ; P= 0 006 ). The particularly strong men familial 2 , P=0.004 allele; OR=3.5, P< 0.0001 allele). OR slightly higher aggressive tumours (Gleason score 8 or more) 5 ), than Gleason 7 below .3). In conclusion, relationship between polymorphic variants on is Polish population similar degree it has elsewhere. Although carcinogenic mechanism locus unclear appears be specific cancer.
cabdirect.org
sci-hub.se 参考文章(32)
Michael L. Cher, Michael L. Cher, William B. Isaacs, G. Steven Bova, Sokhom S. Pin, Dan H. Moore, Peter R. Carroll, Eric J. Small, Jonathan I. Epstein, Ronald H. Jensen, Genetic alterations in untreated metastases and androgen-independent prostate cancer detected by comparative genomic hybridization and allelotyping Cancer Research. ,vol. 56, pp. 3091- 3102 ,(1996)
Xiangyang Dong, Liang Wang, Ken Taniguchi, Xianshu Wang, Julie M. Cunningham, Shannon K. McDonnell, Chiping Qian, Angela F. Marks, Susan L. Slager, Brett J. Peterson, David I. Smith, John C. Cheville, Michael L. Blute, Steve J. Jacobsen, Daniel J. Schaid, Donald J. Tindall, Stephen N. Thibodeau, Wanguo Liu, Mutations in CHEK2 associated with prostate cancer risk. American Journal of Human Genetics. ,vol. 72, pp. 270- 280 ,(2003) , 10.1086/346094
Jianfeng Xu, Latchezar Dimitrov, Bao-Li Chang, Tamara S. Adams, Aubrey R. Turner, Deborah A. Meyers, Rosalind A. Eeles, Douglas F. Easton, William D. Foulkes, Jacques Simard, Graham G. Giles, John L. Hopper, Lovise Mahle, Pal Moller, Tim Bishop, Chris Evans, Steve Edwards, Julia Meitz, Sarah Bullock, Questa Hope, Chih-lin Hsieh, Jerry Halpern, Raymond N. Balise, Ingrid Oakley-Girvan, Alice S. Whittemore, Charles M. Ewing, Marta Gielzak, Sarah D. Isaacs, Patrick C. Walsh, Kathleen E. Wiley, William B. Isaacs, Stephen N. Thibodeau, Shannon K. McDonnell, Julie M. Cunningham, Katherine E. Zarfas, Scott Hebbring, Daniel J. Schaid, Danielle M. Friedrichsen, Kerry Deutsch, Suzanne Kolb, Michael Badzioch, Gail P. Jarvik, Marta Janer, Leroy Hood, Elaine A. Ostrander, Janet L. Stanford, Ethan M. Lange, Jennifer L. Beebe-Dimmer, Caroline E. Mohai, Kathleen A. Cooney, Tarja Ikonen, Agnes Baffoe-Bonnie, Henna Fredriksson, Mika P. Matikainen, Teuvo LJ Tammela, Joan Bailey-Wilson, Johanna Schleutker, Christiane Maier, Kathleen Herkommer, Josef J. Hoegel, Walther Vogel, Thomas Paiss, Fredrik Wiklund, Monica Emanuelsson, Elisabeth Stenman, Björn-Anders Jonsson, Henrik Grönberg, Nicola J. Camp, James Farnham, Lisa A. Cannon-Albright, Daniela Seminara, A Combined Genomewide Linkage Scan of 1,233 Families for Prostate Cancer–Susceptibility Genes Conducted by the International Consortium for Prostate Cancer Genetics American Journal of Human Genetics. ,vol. 77, pp. 219- 229 ,(2005) , 10.1086/432377
E H Seppälä, T Ikonen, N Mononen, V Autio, A Rökman, M P Matikainen, T L J Tammela, J Schleutker, CHEK2 variants associate with hereditary prostate cancer British Journal of Cancer. ,vol. 89, pp. 1966- 1970 ,(2003) , 10.1038/SJ.BJC.6601425
M. L. Freedman, C. A. Haiman, N. Patterson, G. J. McDonald, A. Tandon, A. Waliszewska, K. Penney, R. G. Steen, K. Ardlie, E. M. John, I. Oakley-Girvan, A. S. Whittemore, K. A. Cooney, S. A. Ingles, D. Altshuler, B. E. Henderson, D. Reich, Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 14068- 14073 ,(2006) , 10.1073/PNAS.0605832103
H Tulinius, GH Olafsdottir, H Sigvaldason, A Arason, RB Barkardottir, V Egilsson, HM Ogmundsdottir, L Tryggvadottir, S Gudlaugsdottir, JE Eyfjord, The effect of a single BRCA2 mutation on cancer in Iceland Journal of Medical Genetics. ,vol. 39, pp. 457- 462 ,(2002) , 10.1136/JMG.39.7.457
Stephen M Edwards, Zsofia Kote-Jarai, Julia Meitz, Rifat Hamoudi, Questa Hope, Peter Osin, Rachel Jackson, Christine Southgate, Rashmi Singh, Alison Falconer, David P Dearnaley, Audrey Ardern-Jones, Annette Murkin, Anna Dowe, Jo Kelly, Sue Williams, Richard Oram, Margaret Stevens, Dawn M Teare, AJ Bruce Ponder, Simon A Gayther, Doug F Easton, Rosalind A Eeles, None, Two Percent of Men with Early-Onset Prostate Cancer Harbor Germline Mutations in the BRCA2 Gene American Journal of Human Genetics. ,vol. 72, pp. 1- 12 ,(2003) , 10.1086/345310
Mark van Duin, Ronald van Marion, Kees Vissers, J. E. Vivienne Watson, Wytske M. van Weerden, Fritz H. Schröder, Wim C. J. Hop, Theo H. van der Kwast, Colin Collins, Herman van Dekken, High-resolution array comparative genomic hybridization of chromosome arm 8q: Evaluation of genetic progression markers for prostate cancer Genes, Chromosomes and Cancer. ,vol. 44, pp. 438- 449 ,(2005) , 10.1002/GCC.20259
John S Witte, Multiple prostate cancer risk variants on 8q24 Nature Genetics. ,vol. 39, pp. 579- 580 ,(2007) , 10.1038/NG0507-579
Liang Wang, Shannon K. McDonnell, Joshua P. Slusser, Scott J. Hebbring, Julie M. Cunningham, Steven J. Jacobsen, James R. Cerhan, Michael L. Blute, Daniel J. Schaid, Stephen N. Thibodeau, Two common chromosome 8q24 variants are associated with increased risk for prostate cancer. Cancer Research. ,vol. 67, pp. 2944- 2950 ,(2007) , 10.1158/0008-5472.CAN-06-3186