Possible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancer.

摘要: Over recent years, genome-wide association studies have contributed to our understanding of genetic susceptibility sporadic cancer. In this study, we assessed the between upper gastrointestinal cancer risk and four studies-identified single nucleotide polymorphisms (SNPs), implicated earlier in prostate colorectal susceptibility. Genotyping for each SNP was performed two independent Caucasian population-based case-control studies. The first study comprised 290 gastric cases 374 controls. second included 185 noncardia cancers, 123 cardia 158 oesophageal cancers 209 Odds ratios (ORs) were computed from logistic models adjusted potential confounding variables. An inverse observed rs1447295, located at 8q24, population (OR=0.63; 95% confidence interval: 0.41-0.97). A positive same squamous cell carcinoma (OR=7.43; 1.37-49.98). No significant associations detected either three remaining SNPs (rs6983297, rs10505477 rs719725). Our data represent novel findings on heritable warrant validation additional populations.