Genetic variant in 8q24 is associated with prognosis for gastric cancer in a Chinese population.
作者： Gaoxiang Ma , Dongying Gu , Chunye Lv , Haiyan Chu , Zhi Xu
DOI: 10.1111/JGH.12801
关键词:
摘要: Background and Aim Single nucleotide polymorphisms (SNPs) located in long noncoding RNA CASC8 gene may influence the process of splicing stability messenger RNA conformation, resulting modification its interacting partners. Genome-wide association studies have identified SNP rs10505477 rs1562430 CASC8 were associated with risk colorectal cancer (CRC) breast cancer, respectively. Methods In present study, we genotyped 940 surgically resected gastric patients to explore between these two SNPs (e.g. rs1562430) survival a Chinese population. Results We found that carrying GG genotype survived for longer time than those GA AA genotypes (log-rank P = 0.030). The similar result was also dominant model (GA/AA vs GG, HR = 1.32, 95% CI = 1.08–1.63, log-rank P = 0.008). This effect more pronounced among tumor size ≤ 5 cm, diffuse-type lymph node metastasis, no distant TNM stage III IV. Furthermore, area under curve at five years dramatically increased from 0.619 0.624 after adding score traditional clinical (TNM metastasis). However, there be cancer. Conclusion These findings suggested contribute potential prognostic biomarker cancer.
sci-hub.se 参考文章(42)
Suyoun Chung, Hidewaki Nakagawa, Motohide Uemura, Lianhua Piao, Kyota Ashikawa, Naoya Hosono, Ryo Takata, Shusuke Akamatsu, Takahisa Kawaguchi, Takashi Morizono, Tatsuhiko Tsunoda, Yataro Daigo, Koichi Matsuda, Naoyuki Kamatani, Yusuke Nakamura, Michiaki Kubo, Association of a novel long non‐coding RNA in 8q24 with prostate cancer susceptibility Cancer Science. ,vol. 102, pp. 245- 252 ,(2011) , 10.1111/J.1349-7006.2010.01737.X
S. Lilly Zheng, Jielin Sun, Fredrik Wiklund, Shelly Smith, Pär Stattin, Ge Li, Hans-Olov Adami, Fang-Chi Hsu, Yi Zhu, Katarina Bälter, A. Karim Kader, Aubrey R. Turner, Wennuan Liu, Eugene R. Bleecker, Deborah A. Meyers, David Duggan, John D. Carpten, Bao-Li Chang, William B. Isaacs, Jianfeng Xu, Henrik Grönberg, Cumulative Association of Five Genetic Variants with Prostate Cancer The New England Journal of Medicine. ,vol. 358, pp. 910- 919 ,(2008) , 10.1056/NEJMOA075819
Ian Tomlinson, Kimmo Palin, Esko Ukkonen, Auli Karhu, Jussi Taipale, Lauri A Aaltonen, Sari Tuupanen, Mikko Turunen, Rainer Lehtonen, Outi Hallikas, Sakari Vanharanta, Teemu Kivioja, Mikael Björklund, Gonghong Wei, Jian Yan, Iina Niittymäki, Jukka-Pekka Mecklin, Heikki Järvinen, Ari Ristimäki, Mariachiara Di-Bernardo, Phil East, Luis Carvajal-Carmona, Richard S Houlston, The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling Nature Genetics. ,vol. 41, pp. 885- 890 ,(2009) , 10.1038/NG.406
Ian Tomlinson, Emily Webb, Luis Carvajal-Carmona, Peter Broderick, Zoe Kemp, Sarah Spain, Steven Penegar, Ian Chandler, Maggie Gorman, Wendy Wood, Ella Barclay, Steven Lubbe, Lynn Martin, Gabrielle Sellick, Emma Jaeger, Richard Hubner, Ruth Wild, Andrew Rowan, Sarah Fielding, Kimberley Howarth, CORGI Consortium, Andrew Silver, Wendy Atkin, Kenneth Muir, Richard Logan, David Kerr, Elaine Johnstone, Oliver Sieber, Richard Gray, Huw Thomas, Julian Peto, Jean-Baptiste Cazier, Richard Houlston, None, A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nature Genetics. ,vol. 39, pp. 984- 988 ,(2007) , 10.1038/NG2085
Douglas F Easton, Karen A Pooley, Alison M Dunning, Paul DP Pharoah, Deborah Thompson, Dennis G Ballinger, Jeffery P Struewing, Jonathan Morrison, Helen Field, Robert Luben, Nicholas Wareham, Shahana Ahmed, Catherine S Healey, Richard Bowman, SEARCH collaborators Luccarini Craig 61 Conroy Don 61 Shah Mitul 61 Munday Hannah 61 Jordan Clare 61 Perkins Barbara 61 West Judy 61 Redman Karen 61 Driver Kristy 61, Kerstin B Meyer, Christopher A Haiman, Laurence K Kolonel, Brian E Henderson, Loic Le Marchand, Paul Brennan, Suleeporn Sangrajrang, Valerie Gaborieau, Fabrice Odefrey, Chen-Yang Shen, Pei-Ei Wu, Hui-Chun Wang, Diana Eccles, D Gareth Evans, Julian Peto, Olivia Fletcher, Nichola Johnson, Sheila Seal, Michael R Stratton, Nazneen Rahman, Georgia Chenevix-Trench, Stig E Bojesen, Børge G Nordestgaard, Christen K Axelsson, Montserrat Garcia-Closas, Louise Brinton, Stephen Chanock, Jolanta Lissowska, Beata Peplonska, Heli Nevanlinna, Rainer Fagerholm, Hannaleena Eerola, Daehee Kang, Keun-Young Yoo, Dong-Young Noh, Sei-Hyun Ahn, David J Hunter, Susan E Hankinson, David G Cox, Per Hall, Sara Wedren, Jianjun Liu, Yen-Ling Low, Natalia Bogdanova, Peter Schürmann, Thilo Dörk, Rob AEM Tollenaar, Catharina E Jacobi, Peter Devilee, Jan GM Klijn, Alice J Sigurdson, Michele M Doody, Bruce H Alexander, Jinghui Zhang, Angela Cox, Ian W Brock, Gordon MacPherson, Malcolm WR Reed, Fergus J Couch, Ellen L Goode, Janet E Olson, Hanne Meijers-Heijboer, Ans van den Ouweland, André Uitterlinden, Fernando Rivadeneira, Roger L Milne, Gloria Ribas, Anna Gonzalez-Neira, Javier Benitez, John L Hopper, Margaret McCredie, Melissa Southey, Graham G Giles, Chris Schroen, Christina Justenhoven, Hiltrud Brauch, Ute Hamann, Yon-Dschun Ko, Amanda B Spurdle, Jonathan Beesley, Xiaoqing Chen, AOCS Management Group Bowtell David 146 Green Adele 82 deFazio Anna 147 Chenevix-Trench Georgia 82 Gertig Dorota 111 Webb Penny 82, Arto Mannermaa, Veli-Matti Kosma, Vesa Kataja, Jaana Hartikainen, Nicholas E Day, David R Cox, Bruce AJ Ponder, None, Genome-wide association study identifies novel breast cancer susceptibility loci Nature. ,vol. 447, pp. 1087- 1093 ,(2007) , 10.1038/NATURE05887
Mitchell Guttman, Ido Amit, Manuel Garber, Courtney French, Michael F. Lin, David Feldser, Maite Huarte, Or Zuk, Bryce W. Carey, John P. Cassady, Moran N. Cabili, Rudolf Jaenisch, Tarjei S. Mikkelsen, Tyler Jacks, Nir Hacohen, Bradley E. Bernstein, Manolis Kellis, Aviv Regev, John L. Rinn, Eric S. Lander, Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals Nature. ,vol. 458, pp. 223- 227 ,(2009) , 10.1038/NATURE07672
Lijuan Li, Ruifen Sun, Yundan Liang, Xinmin Pan, Zhaohui Li, Peng Bai, Xiaofeng Zeng, Dongxian Zhang, Lin Zhang, Linbo Gao, Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of colorectal cancer Journal of Experimental & Clinical Cancer Research. ,vol. 32, pp. 104- 104 ,(2013) , 10.1186/1756-9966-32-104
Paul Lochhead, Michael T.H. Ng, Georgina L. Hold, Charles S. Rabkin, Thomas L. Vaughan, Marilie D. Gammon, Harvey A. Risch, Jolanta Lissowska, Indrani Mukhopadhya, Wong-Ho Chow, Emad M. El-Omar, Possible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancer. European Journal of Cancer Prevention. ,vol. 20, pp. 54- 57 ,(2011) , 10.1097/CEJ.0B013E328341E320
Mark M Pomerantz, Nasim Ahmadiyeh, LI Jia, Paula Herman, Michael P Verzi, Harshavardhan Doddapaneni, Christine A Beckwith, Jennifer A Chan, Adam Hills, Matt Davis, Keluo Yao, Sarah M Kehoe, Heinz-Josef Lenz, Christopher A Haiman, Chunli Yan, Brian E Henderson, Baruch Frenkel, Jordi Barretina, Adam Bass, Josep Tabernero, José Baselga, Meredith M Regan, J Robert Manak, Ramesh Shivdasani, Gerhard A Coetzee, Matthew L Freedman, None, The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nature Genetics. ,vol. 41, pp. 882- 884 ,(2009) , 10.1038/NG.403
Silvia Kastler, Lisa Honold, Manuel Luedeke, Rainer Kuefer, Peter Möller, Josef Hoegel, Walther Vogel, Christiane Maier, Guenter Assum, POU5F1P1, a putative cancer susceptibility gene, is overexpressed in prostatic carcinoma. The Prostate. ,vol. 70, pp. 666- 674 ,(2009) , 10.1002/PROS.21100