Association analysis of colorectal cancer susceptibility variants with gastric cancer in a Chinese Han population.
作者： C.-P. Zhou , H.-Z. Pan , F.-X Li , N.-Y. Hu , M. Li
关键词:
摘要: Evidence suggests that some genetic variants are risk factors for both colorectal cancer (CRC) and gastric (GC). Thus, we selected 12 reported single nucleotide polymorphisms (SNPs) from genome-wide association studies of CRC conducted this case-control study to assess the associations between these SNPs GC in a southern Chinese population. All were genotyped 249 individuals with 292 healthy population-matched subjects using Sequenom MassArray iPLEX System. Association analyses based on c2 test binary logistic regression performed determine odds ratio (OR) 95% confidence interval (95%CI) each SNP. A stratified analysis by gender was also performed. Borderline significant observed rs4444235 (P = 0.070) rs10411210 0.084), fitting overdominant model. The CT genotype showed protective effect (OR 0.72, 95%CI 0.50-1.03), while factor 1.40, 0.96-2.05) as compared CC+TT genotype. In female subgroup, rs6983267 GT (compared TT, OR 2.31, 1.07-4.99) rs10505477 2.36, 1.09-5.11) significantly increased GC. No detected other SNPs. These results provide evidence known associated may confer
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