The Experimental Study on the Treatment of Cytokine-Induced Killer Cells Combined with EGFR Monoclonal Antibody Against Gastric Cancer
作者： Lin Zhang , Guangmin Zhao , Yanhong Hou , Jian Zhang , Jing Hu
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摘要: Abstract Aims: To investigate the antitumor activity of cytokine-induced killer (CIK) cells combined with epidermal growth factor receptor (EGFR) monoclonal antibody (mAb) against gastric cancer cell line SGC7901. Materials and Methods: Immunocytochemistry assay was performed to detect expression EGFR in SGC7901 lines. The cytotoxicity CIK mAb analyzed by 51Cr release assay. Then, comparison between CD3 conducted. Antitumor vivo tumor reduction Results: lysis rate higher than those only (p<0.05). rates latter two groups were not different. other gr...
sci-hub.se 参考文章(38)
Freddy Tita-Nwa, Gerhard Moldenhauer, Markus Herbst, Christian Kleist, Anthony D. Ho, Martin Kornacker, Cytokine-induced killer cells targeted by the novel bispecific antibody CD19xCD5 (HD37xT5.16) efficiently lyse B-lymphoma cells. Cancer Immunology, Immunotherapy. ,vol. 56, pp. 1911- 1920 ,(2007) , 10.1007/S00262-007-0333-0
Dario Sangiolo, Cytokine induced killer cells as promising immunotherapy for solid tumors. Journal of Cancer. ,vol. 2, pp. 363- 368 ,(2011) , 10.7150/JCA.2.363
M Moehler, A Mueller, T Trarbach, F Lordick, T Seufferlein, S Kubicka, M Geissler, S Schwarz, PR Galle, S Kanzler, German Arbeitsgemeinschaft Internistische Onkologie AIO, Cetuximab with irinotecan, folinic acid and 5-fluorouracil as first-line treatment in advanced gastroesophageal cancer: a prospective multi-center biomarker-oriented phase II study Annals of Oncology. ,vol. 22, pp. 1358- 1366 ,(2011) , 10.1093/ANNONC/MDQ591
Raphael A. Clynes, Terri L. Towers, Leonard G. Presta, Jeffrey V. Ravetch, Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets Nature Medicine. ,vol. 6, pp. 443- 446 ,(2000) , 10.1038/74704
Nam, Synergistic therapeutic effects of cytokine-induced killer cells and temozolomide against glioblastoma Oncology Reports. ,vol. 25, pp. 33- 39 ,(2010) , 10.3892/OR_00001038
P. Boross, J. H. M. Jansen, S. de Haij, F. J. Beurskens, C. E. van der Poel, L. Bevaart, M. Nederend, J. Golay, J. G. J. van de Winkel, P. W. H. I. Parren, J. H. W. Leusen, The in vivo mechanism of action of CD20 monoclonal antibodies depends on local tumor burden Haematologica. ,vol. 96, pp. 1822- 1830 ,(2011) , 10.3324/HAEMATOL.2011.047159
Xu, Cetuximab enhances the effect of oxaliplatin on hypoxic gastric cancer cell lines Oncology Reports. ,vol. 23, pp. 1735- 1745 ,(2010) , 10.3892/OR_00000819
Hui Li, Changli Wang, Jinpu Yu, Shui Cao, Feng Wei, Weihong Zhang, Ying Han, Xiu-bao Ren, Dendritic cell-activated cytokine-induced killer cells enhance the anti-tumor effect of chemotherapy on non-small cell lung cancer in patients after surgery Cytotherapy. ,vol. 11, pp. 1076- 1083 ,(2009) , 10.3109/14653240903121252
Francesco Sabbatino, Soldano Ferrone, Can the “Right” EGFR-Specific mAb Dramatically Improve EGFR-Targeted Therapy? Clinical Cancer Research. ,vol. 19, pp. 958- 960 ,(2013) , 10.1158/1078-0432.CCR-12-3586
Thomas Leemhuis, Sandra Wells, Christian Scheffold, Matthias Edinger, Robert S. Negrin, A phase I trial of autologous cytokine-induced killer cells for the treatment of relapsed Hodgkin disease and non-Hodgkin lymphoma. Biology of Blood and Marrow Transplantation. ,vol. 11, pp. 181- 187 ,(2005) , 10.1016/J.BBMT.2004.11.019