Clerodendron glandulosum.Coleb extract prevents in vitro human LDL oxidation and oxidized LDL induced apoptosis in human monocyte derived macrophages.
作者： Ravirajsinh N. Jadeja , Menaka C. Thounaojam , Ranjisinh V. Devkar , A.V. Ramachandran
DOI: 10.1016/J.FCT.2011.02.017
关键词:
摘要: Abstract This study reports the protective role of Clerodendron glandulosum (CG) extract against in vitro LDL oxidation and Ox-LDL induced macrophage apoptosis using various experimental models. Effect CG on Cu 2+ mediated kinetics formation intermediary products its ability to prevent human monocyte derived have been investigated. was evaluated by nuclear condensation, cell cycle analysis, annexin V-FITC/PI staining presence or absence extract. Results recorded present clearly suggest oxidative stress, mitochondrial dysfunction, apoptosis. is first report two key events atherosclerosis portending possible therapeutic use as an anti-atherogenic herbal medicine.
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