Update on Staging, Definition, and Chemoprevention of “High-Risk Squamous Cell Carcinoma” in Organ Transplant Recipients

摘要: When compared to the general population, organ transplant recipients (OTRs) have a 65- 250-fold increased risk of developing cutaneous squamous cell carcinoma (SCC). In addition SCC development, OTRs experience higher tumor burden, more aggressive SCCs, and metastasis skin cancer-related mortality, making staging, prognosis, treatment determinations in OTR patients especially important, yet lacking full clarity literature. High-risk SCCs are those tumors associated with high subclinical subsequent adverse events including local recurrence, nodal metastases, disease-specific death. There is concern that current staging systems for may not accurately define “high-risk” SCC, lack prospective data makes it even difficult features immunosuppressed population. With no universally accepted standard definition high-risk features, different factors proposed by several consensus guidelines require individual exploration. also represent desirable target chemoprevention while only oral retinoids shown benefit specifically patients, pertaining other agents warrant review.