Adaptogenic and nootropic activities of aqueous extract of Vitis vinifera (grape seed): an experimental study in rat model

摘要: The aerial parts of Vitis vinifera (common grape or European grape) have been widely used in Ayurveda to treat a variety common and stress related disorders. In the present investigation, seed extract V. was evaluated for antistress activity normal induced rats. Furthermore, studied nootropic rats in-vitro antioxidant potential correlate its activity. For evaluation activity, groups (n = 6) were subjected forced swim one hour after daily treatment extract. Urinary vanillylmandelic acid (VMA) ascorbic selected as non-invasive biomarkers assess 24 h urinary excretion determined by spectrophotometric methods all under stressed conditions. from acquisition, retention retrieval conditioned avoidance response using Cook's pole climbing apparatus. vitro based on ability scavenge hydroxyl radicals. Daily administration at doses 100, 200 300 mg/kg body weight prior induction inhibited biochemical changes dose dependent manner. However, no change VMA observed animals studied. cognition, recovery be dependent. also produced significant inhibition radicals comparison study provides scientific support (adaptogenic), activities substantiate traditional claims usage fruits seeds