Ascaris lumbricoides infection is associated with protection from cerebral malaria.

摘要: SUMMARY Following reports of increased IgE in severe malaria and hypothesizing that helminth coinfections could modify its outcome, we conducted a retrospective case‐control study to establish whether helminths affect the evolution ofPlasmodium falciparum malaria. Some 182 cases, 315 mild controls 40 with circulating schizonts were examined for intestinal helminths. Comparing cerebral controls,Ascaris lumbricoides was associated protective adjusted odds ratio (OR) 0·58 (0·32‐1·03) P o 0·06, coinfection Ascaris Necator americanus, ORo 0·39 (0·17‐0·88) 0·02. Protection followed dose‐effect trend ( 0·008). When comparing cases OR 0·25 (0·009‐0·67) 0·006. We hypothesized infected patients may have had decreased cyto-adherence, possibly through endothelial cell receptor downregulation and/or splenic clearance leading absence selection virulentP. strains. IgE-anti-IgE immune complexes resulting from preinfection an important role influencing clinical presentation malaria, establishing tolerance, CD23/NO pathway.