Adjunctive input to the nuclear thyroid hormone receptor from the cell surface receptor for the hormone.

作者: Paul J Davis , Hung-Yun Lin , Heng-Yuan Tang , Faith B Davis , Shaker A Mousa

DOI: 10.1089/THY.2013.0280

关键词:

摘要: At thyroid hormone response elements on specific genes, complexes of nuclear receptors (TRs) and 3,5,3'-triiodo-L-thyronine (T(3)), coactivator or corepressor nucleoproteins, histone acetylases deacetylases mediate genomic effects the hormone. Nongenomic are those whose initiation does not primarily depend upon formation TR-T(3) complex. Among nongenomic a set actions initiated at cell surface receptor integrin αvβ3 that relevant to a) intracellular trafficking proteins, including TRβ1, b) serine phosphorylation acetylation this receptor, c) assembly within nucleus coactivators corepressor, d) transcription for TRβ1. These reviewed here appear be adjunctive

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