Alexander's disease in an adult. Report of a case.

摘要: PREVIOUS descriptions of Alexander's disease have generally been cases in young children.1-8The clinical picture most often associated with this has one developmental retardation and enlargement the head. Vogel Hallervorden,9however, described a case 15-year-old girl that began weakness left leg foot at age 7 progressed to spasticity contractures lower extremities, eventual upper development blurred vision, nystagmus, dysarthria, dysphagia. The brain was atrophic, weighing 990 gm autopsy. Stevenson,10referring case, stated patient "presented would think might be multiple sclerosis." Rewcastle11presented 26-year-old man whose symptoms 14 legs, followed by arm weakness, incontinence, diplopia, difficulty speech swallowing. Findings on examination included