Altered interferon-γ response in patients with Q-fever fatigue syndrome.
作者： Stephan P. Keijmel , Ruud P.H. Raijmakers , Chantal P. Bleeker-Rovers , Jos W.M. van der Meer , Mihai G. Netea
DOI: 10.1016/J.JINF.2016.01.004
关键词:
摘要: Summary Objectives Whether immunological mechanisms underlie Q-fever fatigue syndrome (QFS) remains unclear. For acute Q-fever, the antigen-specific interferon-γ (IFNγ) response may be a useful tool for diagnosis, and IFNγ/interleukin(IL)-2 production ratio marker chronic treatment monitoring. Here we explored specific IFNγ IFNγ/IL-2 in QFS patients. Methods IL-2 were tested ex-vivo stimulated whole blood of patients (n = 20), compared to those previously determined seropositive controls (n = 135), (n = 28). Also, correlation between patient characteristics IFNγ, IL-2, was determined. Results younger (p Coxiella burnetii Nine Mile stimulation revealed higher (median 319.5 pg/ml) than (120 pg/ml, p Conclusions These results point an altered cell-mediated immunity QFS, suggest different immune Q-fever.
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