Specific in vitro interferon-gamma and IL-2 production as biomarkers during treatment of chronic Q fever

摘要: Background: Antibiotic treatment of chronic Q fever is cumbersome and long duration. To monitor treatment, there a the need for alternative biomarkers. C. burnetii-specific interferon (IFN)-γ interleukin (IL)-2 production reflect type effector memory T-cell response. In fever, IFN-γ higher IL-2 lower than in individuals with past fever. Here we explore whether correlate to Methods: We studied longitudinal IFN-γ/IL-2 ratio fifteen proven patients. All patients were followed at least 18 months during antibiotic treatment. Treatment was considered successful when clinical recovery observed, positive PCR burnetii DNA blood became persistently negative, anti-phase I IgG showed fourfold decrease or more, imaging techniques disappearance infectious foci. Results: Overall, declined experienced outcome. When failed, ratios did not significantly decrease. The median(±IQR) slope -2.10 (-7.02 -0.06), -0.15 (-1.13 0.25) unsuccessful (P=0.19). endocarditis had endovascular infections. Conclusions: propose that can be used as an additional biomarker monitoring declining being indicative